
First Known Case of Severe Mpox Strain Confirmed in California, US
The United States has confirmed its first known case of a more severe strain of mpox, specifically clade I, in California, according to the Centers for Disease Control and Prevention (CDC). Despite this, the agency reassured the public that the overall risk remains low.
The individual diagnosed with clade I mpox had recently traveled from Eastern Africa, where an ongoing mpox outbreak is occurring. After receiving treatment at a local medical facility, the person was released and is currently isolating at home with symptoms improving. The CDC and state health authorities are working to identify and monitor potential contacts.
While clade II mpox has been circulating in the U.S. since the large outbreak in 2022-2023, clade I is responsible for more severe disease and is primarily circulating in Africa. A newer subtype, clade Ib, which is linked to travel-related cases, has been reported in several countries outside of Africa, including Germany, India, Kenya, Sweden, Thailand, Zimbabwe, and the UK. However, no deaths have been reported from these cases, and the disease course has generally been mild.
Historically, clade I mpox was associated with higher mortality rates (around 3-11%), but recent outbreaks have seen death rates as low as 1%, especially when patients receive adequate medical care. The CDC emphasizes that death rates are expected to be much lower in countries with robust healthcare systems like the U.S.
The World Health Organization (WHO) reports a rise in mpox cases in Africa, particularly in the Democratic Republic of Congo, Burundi, and Uganda. On November 22, the WHO will convene its emergency committee to assess whether the current outbreak still constitutes a public health emergency of international concern.
Mpox, previously known as monkeypox, is a viral disease related to smallpox. It spreads through close contact, including touching, kissing, or sexual activity, as well as contaminated materials like sheets, clothing, and needles. Initial symptoms are flu-like, including fever, chills, and fatigue, followed by a painful rash with raised lesions that eventually scab over.
The CDC advises people to avoid contact with those showing symptoms and contaminated materials, and recommends vaccination for those who are eligible, with two doses of the mpox vaccine.
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